For the past two decades, large amounts of isotonic fluids have been the first step in treating septic shock despite adverse events of fluid overload, coagulopathy, and pulmonary edema. A new NIH study evaluates this strategy. Join host, Geoff Wall, with guest, Matt Trump, DO, as they evaluate initial septic shock management.
The GameChanger
Liberal fluid management (30 mL/Kg) in the early phase of septic shock may not result in lower mortality than a more restrictive strategy. However, vasopressor predominant strategy may be used in its place.
Show Segments
00:00 - Introductions
01:08 - Background on Fluid Administration in Septic Shock
05:44 - Looking at the Study
15:55 - The GameChanger: Shapiro et al Results
21:21 - Connecting to Practice: What Should We Takeaway
34:31 - Closing Remarks
Host
Geoff Wall, PharmD, BCPS, FCCP, CGP
Professor of Pharmacy Practice, Drake University
Internal Medicine/Critical Care, UnityPoint Health
Matt Trump, DO
Iowa Clinics
References and Resources
Early Restrictive or Liberal Fluid Management for Sepsis-Induced Hypotension.
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CPE (Pharmacist)
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CE Information
Learning Objectives
Upon successful completion of this knowledge-based activity, participants should be able to:
1. Discuss the background of fluid administration in septic shock
2. Describe the results of the Shapiro et al study
0.05 CEU/0.5 Hr
UAN: 0107-0000-23-103-H01-P
Initial release date: 03/13/2023
Expiration date: 03/13/2024
Additional CPE and CME details can be found here.