Furosemide is the most prescribed loop diuretic for heart failure; however, furosemide’s pharmacokinetic parameters are less than ideal compared to other loop diuretics. Join host, Geoff Wall, as he evaluates the first randomized controlled trial comparing loop diuretics in heart failure.
The GameChanger
Torsemide has potential pharmacokinetic advantages compared to furosemide in the treatment of heart failure. However, a recent study did not find meaningful differences in clinical outcomes when comparing loop diuretics for the treatment of heart failure.
Show Segments
00:00 - Introduction
01:00 - Current Loop Diuretic Use
02:21 - Furosemide vs Torsemide Pharmacokinetics
04:58 - Looking at the TRANSFORM-HF Study
14:54 - The GameChanger: TRANSFORM-HF Outcomes
19:16 - Connecting to Practice: Picking Between the Two
21:52 - Closing Remarks
Host
Geoff Wall, PharmD, BCPS, FCCP, CGP
Professor of Pharmacy Practice, Drake University
Internal Medicine/Critical Care, UnityPoint Health
References and Resources
Effect of Torsemide vs Furosemide After Discharge on All-Cause Mortality in Patients Hospitalized With Heart Failure: The TRANSFORM-HF Randomized Clinical Trial.
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CE Information
Learning Objectives
Upon successful completion of this knowledge-based activity, participants should be able to:
1. List the pharmacokinetic differences between furosemide and torsemide
2. Discuss the findings of the Mentz et al study evaluating loop diuretics
0.05 CEU/0.5 Hr
UAN: 0107-0000-23-101-H01-P
Initial release date: 02/27/2023
Expiration date: 02/27/2024
Additional CPE and CME details can be found here.