The GRADE studies evaluated the pharmacotherapy of diabetes after initiation of metformin – for both micro- and macrovascular outcomes. Join host, Geoff Wall, and guest Jake Galdo as they examine these studies to determine if they are GameChangers in diabetes management.
Insulin glargine and liraglutide had the biggest decrease in A1c; however, many patients still did not reach goal targets. Minor differences in microvascular and macrovascular outcomes were observed.
00:00 - Introductions
1:40 - The GRADE Studies
12:02 - Glycemic Outcomes
16:08 - Microvascular and Cardiovascular Outcomes
21:10 - The GameChanger: Selecting a Second Medication
27:18 - Connecting to Practice: Realistic Diabetes Care
33:17 - Closing Remarks
Geoff Wall, PharmD, BCPS, FCCP, CGP
Professor of Pharmacy Practice, Drake University
Internal Medicine/Critical Care, UnityPoint Health
John A Galdo, PharmD, MBA, BCPS, BCGP (Jake)
Pharmacist, Ross Bridge Pharmacy
References and Resources
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Get a membership & earn CE for GameChangers Podcast episodes (30 mins/episode)
Upon successful completion of this knowledge-based activity, participants should be able to:
1. Select a second medication after metformin in a patient with type 2 diabetes based on the data from the GRADE studies
2. Discuss the results of the GRADE studies
0.05 CEU/0.5 Hr
Initial release date: 10/31/2022
Expiration date: 10/31/2023
Additional CPE and CME details can be found here.
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