Calculating an accurate renal function in patients is crucial to ensure the right dose gets to the right patient. Previous equations to estimate glomerular filtration rate depended on a race variable. However, recent data suggests this underestimates the risk of chronic kidney disease in black patients. In this episode, host Geoff Wall discusses different methods to calculate kidney function and the relationship between mortality, kidney failure, and race
The GameChanger
The newly proposed eGFRcr-cys equation was the most accurate in estimating the relationship of GFR to poor outcomes regardless of race. However, even with this equation, black patients were almost uniformly found to have poorer outcomes than non-black patients
Show Segments
00:00 – Introductions
01:30 – Kidney Function and Kidney Disease
03:00 – Estimating Kidney Function Based on Race
07:44 – Cystatin C vs Creatinine Clearance
09:57 – Association of Estimated GFR Calculated Using Race-Free Equations with Kidney Failure and Mortality by Black vs Non-Black Race
16:11 – The GameChanger
19:25 – Connecting to Practice
21:16 – Closing Remarks
Host
Geoff Wall, PharmD, BCPS, FCCP, CGP
Professor of Pharmacy Practice, Drake University
Internal Medicine/Critical Care, UnityPoint Health
References and Resources
Redeem your CPE or CME here
Get a membership & earn CE for GameChangers Podcast episodes (30 mins/episode)
Pharmacists: Get a membership
Prescribers: Get a membership
CE Information
Learning Objectives
Upon successful completion of this knowledge-based activity, participants should be able to:
1. Describe the equation that best estimates risk of poor outcomes in patients with chronic kidney disease regardless of race
2. List barriers to implementing cystatin-C testing in clinic laboratories
0.05 CEU/0.5 Hr
UAN: 0107-0000-22-280-H01-P
Initial release date: 08/01/2022
Expiration date: 08/01/2023
Additional CPE and CME details can be found here.