CEimpact Podcast
The CEimpact Podcast features two shows:
GameChangers Clinical Updates
Precept2Practice
GameChangers Clinical Update Series:
The GameChangers podcast, hosted by Rachel Maynard, PharmD, features the latest game-changing pharmacotherapy advances impacting patient care. New episodes arrive every Monday. Listeners can purchase the episode to earn CE credit at: https://www.ceimpact.com/resources/podcast/
Precept2Practice
The Precept2Practice podcast, hosted by Kathy Schott, brings you tools to mentor students and residents with confidence. New episodes arrive on the third Wednesday of every month. Preceptor By Design™ subscribers can earn CE credit for each episode.
Give us a follow, tune in regularly, and turn your drive time, coffee break, or chart review into a chance to level up your practice. CEimpact continuing education makes pharmacy learning inspiring!
Check back each week for our latest episodes.
CEimpact Podcast
Treating Breast Cancer with Metformin
Several large observational studies have suggested metformin has anti-tumor effects and may be beneficial as an adjunctive treatment option for breast cancer. This hypothesis was tested by a randomized clinical trial recently published. Listen to host Geoff Wall discuss if metformin is a miracle drug.
The GameChanger
Metformin can alter insulin signaling which is crucial for the development of certain types of cancer cells. Thus, in various observational and pre-clinical studies, metformin has been associated with better outcomes in breast cancer, usually in patients with diabetes. A recently published RCT found no benefit of taking adjunctive metformin in patients with breast cancer and no diabetes.
Show Segments
00:00 – Introductions
01:19 – Metformin in the Treatment of Breast Cancer
02:21 – Insulin Signaling in Tumor Cell Development
06:54 – Effect of Metformin Vs Placebo on Invasive Disease-Free Survival in Patients with Breast Cancer: The MA.32 Randomized Clinical Trial
17:09 – Connecting to Practice & Further Studies
21:17 – The GameChanger
21:55 – Closing Remarks
Host
Geoff Wall, PharmD, BCPS, FCCP, CGP
Professor of Pharmacy Practice, Drake University
Internal Medicine/Critical Care, UnityPoint Health
References and Resources
Effect of Metformin vs Placebo on Invasive Disease–Free Survival in Patients With Breast Cancer: The MA.32 Randomized Clinical Trial
Redeem your CPE or CME here
CPE (Pharmacist)
CME (Physician)
Get a membership & earn CE for GameChangers Podcast episodes (30 mins/episode)
Pharmacists: Get a membership
Prescribers: Get a membership
CE Information
Learning Objectives
Upon successful completion of this knowledge-based activity, participants should be able to:
- Describe the potential mechanism(s) of action of metformin as an anti-tumor agent
- Discuss the MA.32 study and role of metformin in breast cancer treatment
0.05 CEU/0.5 Hr
UAN: 0107-0000-22-248-H01-P
Initial release date: 7/18/22
Expiration date: 7/18/23
Additional CPE and CME details can be found here.